Saul opened the scoring in the 33rd minute with a left-footed finish from inside the box, before Antoine Griezmann scored his third of the campaign to seal the victory.
Atletico Madrid avenged last month’s defeat by Borussia Dortmund to move level on points with the Germans in Champions League Group A.
The victory moves Atletico into second place on goal difference. Both sides need just a point from their next match to qualify for the knockout stage.
Atletico host bottom side Monaco on 28 November (17:55 GMT), while Dortmund welcome Belgian side Club Brugge to Signal Iduna Park on the same day (20:00 GMT) in the penultimate round of group matches. List of the full results of matches played last night.